Summary: The social amoeba Dictyostelium discoideum commonly forms chimeric fruiting bodies.Genetic variants that produce a higher proportion of spores are predicted to undercut multicellular organization unless cooperators assort positively.Cell adhesion is considered a primary factor driving such assortment, but evolution of adhesion has not been
Anaplastic lymphoma kinase (ALK) is one of the common oncogenic driver genes in non-small cell lung cancer (NSCLC).Tyrosine kinase inhibitors (TKIs) have achieved excellent therapeutic effects in patients with ALK fusion positive NSCLC.However, patients will eventually develop resistance to TKIs.Acquired molecular drug resistance mechanisms, such a
Large biological datasets are being produced at a rapid pace and create substantial storage challenges, particularly in the domain of high-throughput sequencing (HTS).Most approaches currently used to store HTS data are either unable to quickly adapt to the requirements of new sequencing or analysis methods (because they do not support schema evolu
Snoring and obstructive sleep apnoea (OSA) are increasingly common conditions, and confer a significant health and socioeconomic burden.Furthermore, untreated OSA represents a significant mortality risk.Patients require careful assessment, including detailed clinical history and examination, sleep study and Ottoman drug-induced sleep endoscopy (DIS
Hypersaline tidal flats (HTF) are ecotones associated with mangrove ecosystems in arid and semiarid coasts.They are predominantly vegetated by halophytes which are related to environmental stabilization and fauna protection.Some plants thrive in HTF by modifying soil biogeochemical conditions at their rhizospheres, expanding across barren soils.Thu